Adalimumab: Uses, Side Effects, Dosage

Adalimumab

  • Adalimumab is an anti-TNF drug. In rheumatoid arthritis and some other conditions, too much of a protein called TNF (tumour necrosis factor) is produced in the body, causing inflammation, pain and damage to the bones and joints. Anti-TNF drugs such as adlimumab block the action of TNF and so reduce this inflammation.
  • Adalimumab isn’t a painkiller but can modify the disease and improve your symptoms over a period of 2–12 weeks.
  • Trade name Of Adalimumab is Humira)

Adalimumab Uses

Adalimumab can be prescribed by a rheumatologist for:

  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Psoriatic arthritis
  • Juvenile idiopathic arthritis (JIA).

It’s often prescribed along with a disease-modifying drug such as methotrexate.

Side Effects:

If you have any of these serious side effects of Humira, stop taking it and call your doctor right away:

  • Vision problems
  • Numbness or tingling
  • New joint pain
  • Weakness in your legs
  • Chest pain
  • Shortness of breath
  • Swelling of the face, feet, ankles, or lower legs
  • Hives
  • Itching
  • Unusual bruising or bleeding
  • Rash on your cheeks or arms that gets worse in the sun
  • Trouble breathing or swallowing
  • Fever, sore throat, chills, and other signs of infection
  • Dizziness
  • Pale skin
  • Red, scaly patches or raised, pus-filled bumps
  • Injection site reactions are common while taking Humira.

Symptoms of these reactions, which typically clear up within a few days, may include:

  • Swelling
  • Redness
  • Bruising
  • Itching

Other common side effects of Humira include:

  • Nausea
  • Headaches
  • Upper respiratory infections (including sinus infections)
  • Rash
  • Back pain

Doses:

According To Drugs.com

  • Usual Adult Dose for Ankylosing Spondylitis
    40 mg subcutaneously every other week
  • Usual Adult Dose for Rheumatoid Arthritis
    40 mg subcutaneously every other week
  • Usual Adult Dose for Psoriatic Arthritis
    40 mg subcutaneously every other week
  • Usual Adult Dose for Crohn’s Disease – Acute
    -Initial dose: 160 mg subcutaneously on Day 1 (given in one day or split over 2 consecutive days), followed by 80 mg subcutaneously 2 weeks later (Day 15)
    -Maintenance dose (beginning 2 weeks later [Day 29]): 40 mg subcutaneously every other week
  • Usual Adult Dose for Crohn’s Disease – Maintenance
    -Initial dose: 160 mg subcutaneously on Day 1 (given in one day or split over 2 consecutive days), followed by 80 mg subcutaneously 2 weeks later (Day 15)
    -Maintenance dose (beginning 2 weeks later [Day 29]): 40 mg subcutaneously every other week
  • Usual Adult Dose for Ulcerative Colitis
    -Initial dose: 160 mg subcutaneously on Day 1 (given in one day or split over 2 consecutive days), followed by 80 mg subcutaneously 2 weeks later (Day 15)
    -Maintenance dose (beginning 2 weeks later [Day 29]): 40 mg subcutaneously every other week
  • Usual Adult Dose for Uveitis
    -Initial dose: 80 mg subcutaneously
    -Maintenance dose: 40 mg subcutaneously every other week, starting one week after the initial dose
  • Usual Adult Dose for Plaque Psoriasis
    -Initial dose: 80 mg subcutaneously
    -Maintenance dose: 40 mg subcutaneously every other week, starting one week after the initial dose
  • Usual Adult Dose for Hidradenitis Suppurativa
    -Initial dose: 160 mg subcutaneously (given in one day or split over 2 consecutive days), followed by 80 mg subcutaneously 2 weeks later (Day 15)
    -Maintenance dose: 40 mg subcutaneously each week beginning on Day 29
  • Usual Pediatric Dose for Juvenile Idiopathic Arthritis
    2 years and older:
    -For 10 kg (22 pounds) to less than 15 kg (33 pounds):10 mg subcutaneously every other week
    -For 15 kg (33 pounds) to less than 30 kg (66 pounds): 20 mg subcutaneously every other week
    -For 30 kg (66 pounds) or greater: 40 mg subcutaneously every other week
  • Usual Pediatric Dose for Crohn’s Disease – Acute
    6 years and older:
    -For 17 kg (37 pounds) to less than 40 kg (88 pounds):
    Initial dose: 80 mg subcutaneously (Day 1), then 40 mg subcutaneously 2 weeks later (Day 15)
    Maintenance dose: 20 mg subcutaneously every other week
    -For 40 kg (88 pounds) or greater:
    Initial dose: 160 mg subcutaneously (Day 1) given in one day or split over 2 consecutive days, then 80 mg subcutaneously 2 weeks later (Day 15)
    Maintenance dose: 40 mg subcutaneously every other week
  • Usual Pediatric Dose for Crohn’s Disease – Maintenance
    6 years and older:
    -For 17 kg (37 pounds) to less than 40 kg (88 pounds):
    Initial dose: 80 mg subcutaneously (Day 1), then 40 mg subcutaneously 2 weeks later (Day 15)
    Maintenance dose: 20 mg subcutaneously every other week
    -For 40 kg (88 pounds) or greater:
    Initial dose: 160 mg subcutaneously (Day 1) given in one day or split over 2 consecutive days, then 80 mg subcutaneously 2 weeks later (Day 15)
    Maintenance dose: 40 mg subcutaneously every other week

 

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