Pregabalin: Uses, Side effects, Dosage

Pregabalin is a GABA Analog, Which is similar to Gabapentin. Pregabalin is an antiseizure Or anticonvulsant Drug Used to Treat Painful Nerve Disease Such as Postherpetic Neuralgia and Is also Used to treat Fibromyalgia,And Spinal Cord Injury.

  • It works by reducing the abnormal electrical activity in the brain. It is given in combination with other drugs for the treatment of epilepsy.
  • It is also used for the treatment of symptoms of generalized anxiety disorder (GAD).
  • The Exact Mechanism OF Action is unknown However It’s thought to work by binding to calcium channels found on nerve cells in the brain and spinal cord. This reduces the release of various neurotransmitters Like Glutamate and Nor epinephrine from these nerve cells.These two chemical substances are responsible for transmitting Pain signals in the brain and spinal cord. As Pregabalin Reduces the release of these substances that’s the reason they are used in the treatment of Nerve Pain.It inhibit the voltage gated N type of calcium channels and prevent the entry of calcium into the presynaptic neurons.This will prevent the depolarization of these neurons.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine (pregabalin capsules) affects you.
  • There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.therefore women of child bearing potential should discuss with a health care provider the impact of both epilepsy and its treatment on the outcomes of pregnancy.
  • It is Used Orally in a Dose of 600 mg daily in 2-3 divided Doses.

 

SIDE EFFECTS:

The most common side effects of Pregabalin are

  • Blurred vision,
  • Drowsiness,
  • Dizziness,
  • Edema (accumulation of fluid),
  • Dry mouth ,
  • Fatigue (tiredness),
  • Double vision (diplopia),
  • Difficulty concentrating.
  • Weight gain,
  • Abnormal gait (ataxia),
  • Tremor

Other side effects include

  • Increased appetite
  • Constipation,
  • Flatulence,
  • Nausea,
  • Vomiting,
  • Disorientation,
  • Amnesia,
  • Increased blood creatinine kinase levels
  • Heart failure,
  • Low blood pressure,
  • Reduced blood platelet counts, and
  • Myoclonus.
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