Lamotrigine is an anti-epileptic also known as an anticonvulsant and is employed in the treatment of partial seizures, particularly when used along with other antiseizure medicine.Some clinical studies also show that it’s also effective as a single dose in the treatment of partial seizures.It is also effective in the treatment of absence and myoclonic seizures in the children.It may also be helpful for the prevention of depression that may occur after the manic phase of bipolar disorder.
Its mechanism of action of is comparable to that of phenytoin, that inhibits the voltage-gated sodium and Ca channels. its effectiveness in absence seizures seems to be due to its blocking effect on the voltage-activated Ca channels.Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which can lead to a reduction of pain-related transmission of signals on nerve fibers.
The more common side effects that may occur with use of lamotrigine include: drowsiness dizziness, nausea, and emesis, abdomen pain, insomnia, stuffy nose, dry mouth, rash, anxiety, double vision, headache, blurred vision, diarrhea, trouble with balance and coordination, back pain, pharyngitis, fever, tremor.While Serious side effects and their symptoms will include the following: aseptic meningitis, Serious skin rashes known as Stevens-Johnson syndrome and toxic dermal necrolysis, Changes in mood or behavior, Multi-organ hypersensitivity, that is also known as drug reaction with eosinophilia and systemic symptoms (DRESS), Low blood cell counts.
During pregnancy, Lamotrigine ought to be used only if clearly needed. it may damage an unborn baby. However, since untreated seizures or mental/mood issues (such as bipolar disorder) are serious conditions that may damage both a pregnant lady and her unborn baby, don’t stop taking this medication unless directed by your doctor. If you’re coming up with a pregnancy, become pregnant, or assume you’ll be pregnant, immediately discuss with your doctor regarding the advantages and risks of using this medication throughout pregnancy.
The dose of 100-300 mg per day if given along with valproic acid, the initial dose is reduced to 25 mg on alternate days.this is done as a result of inhibition of its metabolism by valproic acid.