Trimebutine (Brand Name: Debridat) is a drug with antimuscarinic and weak mu opioid agonist effects.This Drug belong to a group of medicines known as spasmolytics.
Debridat contain Trimebutine maleate 100mg as an active ingredient.
Trimebutine is not a FDA-approved drug, but it is available in several countries including Canada.
Trimebutine is used in the following conditions:
- It Helps regulate movement of the intestinal tract.
- It is used to treat symptoms of irritable bowel syndrome IBS (spastic colon).
- It may also be used after intestinal surgery.
- Used in Digestive disorders such as abdominal pain & cramps, spasms, flatulence, diarrhoea &/or constipation.
- It may also be used for the purpose not listed above.
Debridat Mechanism Of Action
It is suggested that trimebutine binds with high affinity to the inactivated state of the calcium channel. The decrease in calcium influx reduces the depolarization of the membrane and reduces the peristalsis of the colon. It also inhibits external K + currents in response to depolarization of smooth muscle cells GI resting to the membranes, which by inhibiting K + channels delayed rectifier and K + channel-dependent Ca2 +, which induces muscle contraction. Trimebutine binds to mu opioid receptors with more selectivity compared to delta or kappa opioid receptors but with lower affinity than their natural ligands. Metabolites (N-monodesmethyl-nor-trimebutine or trimebutine) at opoid receptors also bind to brain membranes and myenteric synaptosomes.
Avoid debridat if
- You take other medicines. This includes all medications you take that you can buy without a prescription like herbal and complementary medicines.
- If You are allergic to any ingredient of Debridat or other medicines.
- It should not be used if you are hypersensitive to any of the ingredients in Debridat.
- Being Pregnant or Breastfeeding Because while you are waiting or feeding a baby, you should take medication only on the recommendation of a doctor.
Debridat in Pregnancy and Lactation?
The use of trimebutine during pregnancy while taking this drug is not recommended. It is not known if debridate can enter breast milk as it may affect your baby. Talk to your doctor if you should continue to breastfeed if you are a nursing mother and you are taking this medication.
Debridat Side Effects:
- Abdominal pain
- Dry mouth
- Foul taste,
- Headache may occur.
Trimebutine may interact with tubocurarine so stop taking one of the medications or change one of the medicine to other and talk to your Doctor or Pharmacist.
How to Take Debridat?
- Take Debridat before meals with your mouth.
- Shake the suspension well before measuring a dose. Use a measuring cup, spoon or dropper to measure the specified dose of the suspension.
- Take debridat usually three times a day. Do not increase your dose, take it more often, or take it longer than prescribed.