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Bromazepam (Lexotan): Uses, Side Effects, Dosage

Bromazepam (Brand Name: Lexotan)  is a Schedule IV benzodiazepines with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties and is used in the treatment of anxiety disorders.

Lexotan come in two strength

Lexotan 1.5 mg Tablets:

Each tablet contains 1.5 mg bromazepam

Lexotan 3 mg Tablets:

Each tablet contains 3 mg bromazepam.

Lexotan Uses

Lexotan is used for the following conditions

  • For the short-term treatment of insomnia.
  • Nervousness and tension
  • Short-term treatment of anxiety or panic attacks.

 

Lexotan Mechanism of action

Bromazepam binds to the GABA(A) receptor, which produces a conformational change and enhances the inhibitory effects of GABA. Other neurotransmitters are not affected.

Side Effects

Following are some of the side effects associated with the use of bromazepam

  • Drowsiness,
  • Constipation
  • Delayed reactions
  • Dizziness, or loss of coordination may occur.
  • Dry mouth,
  • Headache or stomach upset rarely occurs.
  • Rapid or irregular heartbeat,
  • Changes in vision,
  • Slurred speech,
  • Confusion,
  • Depression,
  • Behavior changes.
  • Anterograde amnesia
  • Allergic reaction like: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Contra-Indications:

Lexotan is contraindicated In patients with

  • Known hypersensitivity to benzodiazepines,
  • Myasthenia gravis,
  • Severe hepatic insufficiency,
  • Severe respiratory insufficiency, or
  • Sleep apnea syndrome.

Pregnancy & Breastfeeding

Lexotan is not recommended for use during pregnancy. Consult your doctor before using this medication. Bromazepam may be excreted into breast milk and may have undesirable effects on a nursing infant.

Interactions

Tell your doctor of all prescription and nonprescription medication you may use.

Bromazepam may potentiate or interact with the effects of other CNS acting drugs such as

  • Alcohol,
  • Narcotics,
  • Hypnotics,
  • Sedative antihistamines,
  • Antipsychotics,
  • Anxiolytics/sedatives,
  • Anesthetics,
  • Antidepressants and
  • Anticonvulsants.

Dosage

 

The dose is based on your state of health and the response to the treatment. If your doctor tells you to take this medicine on schedule, use it regularly to get the most out of it. To remember, use it every day at the same time.

The recommended starting dose of bromazepam for adults is between 6 mg and 18 mg daily in divided doses.

Adults: beginning; 6 to 18 mg / day in divided doses, depending on the severity of the symptoms and the patient’s response. Treatment should be started at lower doses and adjusted if necessary. The optimal dose may vary in individual patients in divided doses of 6 to 30 mg daily. There is limited experience with higher doses of up to 60 mg per day.

Elderly and debilitated patients: The initial daily dose in these patients should not exceed 3 mg in divided doses. This dosage can be adjusted carefully, depending on the tolerance and the patient’s response.

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