Butamate citrate (brand name: Sinecod) belongs to a group of medicines known as central antitussive drugs. It is used as cough suppresant. It can also be used for other conditions. It is manufactured by Novartis Consumer Health Sa.

Sinecod comes in various forms such as oral drops, tablets, suspension and syrup, but is most often available as a syrup.

Composition

Each Sinecod Syrup Contain Butamirate Citrate 7.5mg/5ml (100 ml or 200 ml)

Each sustained-release film-coated tablet contains 50 mg of butamirate citrate.

Oral drops for children 5mg/1ml

Sinecod Uses

Sinecod is used for the treatment of the following medical conditions;

  • Symptomatic Treatment of Cough
  • Cough associated with pertussis
  • Dry cough
  • Cough suppression in pre- and postoperative procedures.

It may also be used for the purpose not listed Here.

Sinecod Side Effects:

Sinecod is Generally well tolerated but like all medicine there are some very rare side effects associated with the use of this drug.

  • Allergic reactions
  • Skin rash,
  • Nausea,
  • Vertigo (Very rare)
  • Diarrhea,
  • Dizziness.

Mechanism Of Action:

Butamirate citrate (Sinecod) belongs to a new class of drugs that act centrally through receptors in the brainstem. The exact mechanism of action of butamirate is unknown. Butamirate citrate has non-specific anticholinergic and bronchospasmolytic effects that facilitate respiratory function by binding to the center of the cough in the brain. In addition, it has a very beneficial effect as it reduces resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect.

Precautions:

  • Sinecod is contraindicated in patients with Hypersensitivity or allergy to Butamirate.
  • Sinecod should not be used during pregnancy, especially during the first trimester. If you are pregnant, planning to become pregnant.
  • Should not be used in Patient with diabetes mellitus.
  • Butamiratе Syrup should be used with caution if you drive or use machines as It may cause drowsiness and dizziness.
  • Butamirate should not be prescribed to children less than 3 years of age.
  • Avoid Or Talk To Your Doctor If you have kidney or liver problems because you may be more likely to get side effects.
  • Avoid Co-administration of this drug with other expectorant like bromhexin (Bisolvon).
  • Inform Your doctor before using sinecod with other OTC, herbal supplements.

Dosage

Sinecod Syrup Dose

  • Usual Dose for Children age 3-6 years is 5ml 3 times per day.
  • Usual Dose for Children Age 6-12 Years is 10ml times per day.
  • Usual Dose For Children age 12 years or more is 15ml 4 Times per day.

Sinecod Tablets Dose

  • Usual Adult odse is 2-3 tab daily at 8- or 12-hr intervals
  • Usual Adolescent age more than 12 yr is 1-2 tab daily
  • The maximum dose should not exceed 90 mg/day.
  • As a modified-release formulation, consider administration of 50 mg, twice or thrice daily.

If you miss a dose, use it as soon as you notice. When it’s time for next dose, skip the missed dose and continue dosing. Do not use an extra dose to make up for a missed dose. If you miss regular doses, you should set an alarm or have someone from your family call you back. Please consult with your doctor to discuss any changes in your dosage regimen or schedule to make up for lost dosages if you have missed too many doses lately.

Storage

  • Store medicines at room temperature, protected from heat and direct light.
  • Do not freeze drugs unless they are prescribed in the package leaflet.
  • Keep medicines away from children and pets.
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