A research, published in the British Journal of Pharmacology, showed that both proteins significantly reduced the growth of almost all cancers and blocked the work of specific receptors on the surface of cells that led to division. Biologists found that the number of cancer cells decreased by 40-70% after one day compared to the tumor control samples.
Molecular biologists from the Moscow State University and the Russian Academy of Sciences have discovered proteins that can suppress the growth of cancerous tumors.
The genomes of humans and other multicellular organisms contain multiple groups of genes with special “instructions” that prompt their cells to self-destruct when certain conditions are met. As a rule, these reactions are not triggered by internal cellular processes, but by the contact of cell membranes with molecules emitting specific signals. As a result, the immune system can kill “rebellious” cells that threaten to cause cancerous tumors and purify the organism of old and weak cells.
Dr. Mikhail Shulepko the Institute of Biochemistry of the Russian Academy of Sciences, co-author of a new study on the subject stated that special proteins in skin cells of mammals have a similar toxins of the structure snakes and other reptiles. Unlike their toxic “cousins”, which work to block the transmission of nerve impulses, mammalian proteins called SLURP do not act in the nervous system, but in all cells in general and accelerate or slow their growth
The discovery of the scientists prompted them to consider whether such proteins could be used to fight cancer as a kind of “stop sign” against the proliferation of cancer cells. They tested this idea by cultivating skin, breast, lung and rectal cells in a laboratory and treating them with large amounts of the SLURP-1 and SLURP-2 type of proteins.
Injecting large amounts of SLURP-1 and SLURP-2 proteins into the cell broth also caused the cancer cells to produce even more of these same molecules, causing a chain reaction and destroying the cancer cells themselves.
“We will continue to investigate how SLURP works in other models of cancer, including cell cultures of primary tumors and human tumors implanted in the bodies of laboratory animals. If these effects are confirmed, it will be possible to view clinical trials for our protein, “he said. Shulepko.
According to biologists, more work is needed to determine how exactly these proteins cause cancer cells to self-destruct and what role they play in the body’s work.