Ketoprofen (Brand Name: Profenid) Belong to a group of drugs called Non Steroidal Anti-inflammatory Drugs (NSAIDs).

It is used for Rheumatoid arthritis, Osteoarthritis, tooth extraction pain, Acute gout, Inflammation in backbone, Inflammation in spinal, Painful menstruation, Inflammation after soft tissue injuries,Swollen joints,and other conditions.

Mechanism Of Action

Ketoprofen (Profenid)  is used for its antipyretic, analgesic and anti-inflammatory properties by cyclooxygenase-1 and -2 (COX-1 and COX-2) Enzymes reversibly inhibits, which reduces the production of pro-inflammatory prostaglandin precursors. This results in a decrease in prostaglandin levels that mediates pain, fever and inflammation.

Profenid Uses:

Ketoprofen is used in the Treatment,Prevention and Control of the following symptoms and diseases.

  • Profenid (Ketoprofen) is used to relieve pain from various conditions.
  • It also reduces pain, swelling, and joint stiffness from arthritis.
  • This medication is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body’s production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.
  • Tooth extraction pain.
  • Acute gout.
  • Inflammation in backbone.
  • Rheumatoid arthritis.
  • Osteoarthritis.
  • Inflammation in spinal.
  • Painful menstruation.
  • Used in musculoskeletal disorder such as low back pain, sciatica, bursitis, synovitis, tendinitis and fibrositis.

Note: Ketoprofen (Profenid)  may also be used for purposes not listed in this medication guide.

Profenid (Ketoprofen) Side Effects

The more common side effects that can occur with ketoprofen include:

  • Nausea
  • Diarrhea
  • Stomach upset
  • Drowsiness
  • Headache
  • Dizziness

Serious side effects and their symptoms can include the following:

  • Heart attack or stroke.
  • Kidney damage
  • Heart failure.
  • Stomach problems, such as ulcers or bleeding.
  • Liver problems.
  • Skin reactions.
  • Allergic reactions.
Black Box Warning:
Non-steroidal anti-inflammatory drugs (including ketoprofen) may rarely increase the risk of heart attack or stroke. The risk may be higher if you have heart disease or an increased risk of heart disease (for example due to smoking, heart disease in the family or conditions such as high blood pressure or diabetes) or prolonged use. This medicine should not be taken immediately before or after cardiac bypass surgery (CABG). Ask your doctor about the benefits and risks of taking this medicine. Occasionally, this drug can cause severe (rarely fatal) bleeding in the stomach or intestine. This effect can occur without warning at any time while taking this medicine. Older adults may be at greater risk for this effect.

Contraindications

Profenid Tablet is a contraindicated in case of Hypersensitivity. In addition, Profenid Tablet should not be used if you have the following conditions:
  • Gastrointestinal bleeding
  • Active peptic ulcer
  • Alcohol
  • Breastfeeding.

Interaction With Other Drugs

Profenid Tablet may interact with the following drugs and products:

This can increase the risk of side effects or can make your medication not work properly. Tell your doctor about all the medicines, vitamins, and herbal supplements you use to help your doctor prevent or control drug interactions.

Profenid in pregnancy

Taking ketoprofen (Profenid) during the last 3 months of pregnancy can harm the unborn baby. Do not use this medicine without medical advice if you are pregnant.

Profenid in Breastfeeding 

It is not known if ketoprofen passes into breast milk or if it could harm a baby. Do not use this medicine without medical advice if you are breast-feeding a baby.

Dosage

The recommended initial dose is 100 to 200 mg per day, which is taken regularly throughout the day in unit doses of 50 mg with food.

It is important that you use the lowest dose that relieves pain. Ketoprofen should not be taken longer than necessary to control the symptoms.

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