Mebeverine (Duspatalin) belongs to the group of medicines called antispasmodic. It helps relax the intestinal muscles, which in turn reduces pain and irritability.

Duspatalin Uses

Mebeverine is used to treat the following conditions.

  • Symptoms of irritable bowel syndrome, a common intestinal disease that causes spasms and intestinal pain, as well as stomach pain, persistent diarrhea (sometimes alternating with periods of constipation) and wind (flatulence).
  • It is used to relax the muscles of the intestine and to treat the symptoms of irritable bowel syndrome and related conditions.
  • It is a direct relaxant of the intestinal muscle and is sometimes referred to as an anticonvulsant.
  • Chronic irritable large bowel, spastic constipation, mucosal colitis and spastic colitis.
  • Inflammation of the digestive tract
  • Bile duct disease,
  • Inflammation of the digestive system,
  • Gall bladder disease.

Mechanism of action

Mebeverine hydrochloride is a type of medicine called an antispasmodic. Relax the muscles in the intestinal walls. This relieves painful muscle spasms in the intestine and reduces associated symptoms such as cramping, pain and abdominal cramps, flatulence, winds (flatulence) and diarrhea with constipation.

Duspatalin Side effects

Duspatalin can cause such side effects:

  • Allergic reactions (angioedema, urticaria, rash and swelling of the face)
  • Diarrhea
  • Constipation.
  • Dizziness (very rare)
  • Breathing and swelling of the hands and face.

Duspatalin in pregnancy

It is a category B medicine, that is, it has not been used safely during pregnancy due to possible adverse effects on fetal development. Therefore, Duspatalin is not recommended during the first trimester of pregnancy and, otherwise, a risk-benefit approach should be considered in pregnant women. While mebeverin is excreted in breast milk (<10 micrograms / ml after an oral dose of 100 mg of mebeverine hydrochloride).

Duspatalin is contraindicated in patients with hypersensitivity to mebeverine or other excipients.

Interaction of Mebeverin with other drugs

Duspatalin with omeprazole/lansoprazole

There are no known serious interactions between mebeverine and omeprazole / lansoprazole.

Duspatain with Imodium/Loperamide

There are no known serious drug interactions between mebeverine and imodium / loperamide.

Mebeverine with Buscopan contains butylcopolamine, which, like mebeverin, is also anticonvulsant. The concomitant use of Mebeverine and Buscopan leads to an additional effect, but may cause additional side effects.

Mebeverin with paracetamol

There are no known serious drug interactions between mebeverine and paracetamol and preparations containing codeine with paracetamol.

Mebeverin with antibiotics

There are no known serious interactions between mebeverine and antibiotics.

Ask your doctor about all medications taken before and during the course of taking mebeverin

Dosage of Duspatalin

It is taken orally 20 minutes before a meal without chewing or drinking water. Another dose is a tablet three times a day.

Children over 12 years old should use the medication twice a day (200 mg). The capsule should be swallowed without chewing and should be drunk with water. The duration of the cure is determined individually by the doctor.

Duspatalin should not be used in children 3 years old or younger as there is no clinical data available.

How to store?

  • Store in a cool, dry place, away from heat and direct light.
  • Keep all medications out of the sight and reach of children.

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