Enoxaparin (Clexane): Uses, Side Effects, Doses

Enoxaparin (Brand Name: Clexane) is used to thin blood. It prevents your blood from forming clots. Blood clots are dangerous because they may create serious blockages in your arteries. This may result in a stroke or a heart attack.

Clexane is used to reduce blood clots in people that are hospitalized. It might be used if you are too sick to maneuver around or if you are having a heart attack.

Enoxaparin might be utilized as part of a combination treatment. As a consequence, that you might want to take it together with different drugs. Follow your doctor’s instructions carefully because you might want to begin or discontinue this medication or another blood thinner at particular times.

Additionally, it is utilized to stop blood clots in your home once you have had stomach surgery or even a knee or hip replacement. This medication can also be utilized to deal with present blood clots from the hospital or in home. A blood clot may be treated in the home so long as it’s not on your lungs.

Mechanism

Enoxaparinbinds to and potentiates antithrombin (a circulating anticoagulant) to make a complex that irreversibly inactivates clotting factor Xa. It’s less action from factor IIa (thrombin) compared to unfractionated heparin (UFH) due to the low molecular weight.

Contraindications

Clexane is contraindicated in the following conditions

• Thrombocytopenia associated with a positive in vitro test for anti-platelet antibody in the presence of enoxaparin sodium
• Active Key bleeding
• Known hypersensitivity to enoxaparin sodium (e.g., pruritus, urticaria, anaphylactic/anaphylactoid responses )
• Known hypersensitivity to heparin or pork products Known hypersensitivity to benzyl alcohol (that can be in just the multi-dose formula of Clexane

Clexane In Pregnancy

Clexane is currently in Pregnancy Category B, as stated by the FDA, meaning animal studies haven’t revealed evidence of injury to the developing baby but no adequate studies are performed in pregnant women.

Black-Box Warning

Clexane includes a black-box warning describing its use in patients with spinal or epidural anesthesia or spinal puncture carries an increased risk of bleeding and swelling. This swelling and bleeding can cause long-term or permanent paralysis.

If you’re on Clexane  then you’ll have to have blood tests periodically to determine how well it’s functioning.

Side effects

The common side effects of enoxaparin can comprise:

• Bleeding
• Anemia
• swelling and pain at the site in the skin where you provide the injection
• Fever
• Swelling in your legs

Serious side effects include

• Rebound stroke.
• Bleeding.
• Rebound blood clots.

Drugs Interactions:

Dose for enoxaparin

• Dose for Preventing deep vein thrombosis following abdominal operation is 40 mg subcutaneous injection once every day.
• Dose for Preventing deep vein thrombosis following hip replacement: 30 mg every 12 hours or 40 mg once per day by subcutaneous injection.
• Treatment of deep vein thrombosis or pulmonary embolism: 1 mg/kg each 12 hours or 1.5 mg/kg once per day by subcutaneous injection.
• Dose for the Treatment of acute heart attacks (ST altitude myocardial infarction or STEMI): For individuals below the age of 75, 30 mg orally and one mg/kg subcutaneously followed by 1 mg/kg every 12 hours (max of 100 mg to each of their initial two subcutaneous doses only). For individuals over age 75, 0.75 mg/kg subcutaneously every 12 hours (max of 75 mg to each of their initial 2 subcutaneous doses only). All patients should get aspirin.
• Dose For coronary artery stent processes (percutaneous coronary intervention or PCI).Patients must get 0.3 mg/kg through stent placement if the previous dose of Lovenox was administered over 8 hours prior to the procedure.
• Dose for the Treatment of chest pain (Unstable angina) or moderate heart attack (non-Q-wave myocardial infarction) is 1 mg/kg subcutaneously every 12 hours using aspirin.