Combiflam Tablet is the combination of two active ingredients such as Ibuprofen and Paracetamol.

  • Ibuprofen belongs to group of drugs known as nonsteroidal anti-inflammatory drug (NSAID).
  • Acetaminophen or Paracetamol  belongs to a class of drugs called analgesics (pain relievers) and antipyretics (fever reducers).
It may be used for headache, fever, muscle pain and menstrual cramps.
Combiflam Tablet is manufactured by Sanofi Aventis.
Combiflam Tablet is composed of the following active ingredients (salts)

Combiflam Tablet Uses

Combiflam Tablet is especially suitable for pain which requires stronger analgesia than ibuprofen or paracetamol alone.
Combiflam is used for the treatment and prevention, of the following diseases, conditions and symptoms:
  • Headache
  • Febrility
  • Cold
  • Flu
  • Fever
  • Ear pain
  • Cephalalgia
  • Pain in teeth
  • Analgesic
  • Back pain
  • Joints pain
  • Muscles pain
  • Pain in nerves
  • Pain in body
  • Menstruation pain
  • Periods pain
  • Toothache
  • Joint pain

Combiflam Mechanism

Combiflam is the combination of two active ingredients such as ibuprofen and paracetamol.

Ibuprofen is a nonselective inhibitor of an enzyme called cyclooxygenase (COX), which is required for the synthesis of prostaglandins via the arachidonic acid pathway. COX is needed to convert arachidonic acid into prostaglandin H2 (PGH2) in the body. This PGH2 is then converted to prostaglandins. The inhibition of COX by ibuprofen therefore reduces the amount of prostaglandins produced by the body.

Paracetamol selectively inhibits COX activity in the brain, which may contribute to its ability to treat fever and pain. This activity does not seem to be a direct inhibition when an active site is blocked, but it reduces COX that needs to be oxidized to function. ,

The combination of ibuprofen and paracetamol blocks the production of these chemicals in the body that cause pain, fever, swelling and inflammation.

Precautions

Consult your doctor before using this drug if:

  • You are allergic to ibuprofen or paracetamol or any other medication.
  • You have a stomach ulcer
  • You have asthma
  • You have a bleeding disorder
  • you are taking blood-thinning medication
  • you are taking other medication.

Contraindications

This medication is contraindicated in the following conditions:

  • Hypersensitivity
  • Gastrointestinal bleeding
  • Active peptic ulcer
  • Hepatic impairment

Combiflam in Pregnancy:

Combiflam Tablet may be unsafe during pregnancy. Studies in animals have shown adverse effects on the fetus, but there are limited human studies. The benefits of using it in pregnant women may be acceptable despite the risk. Please consult your doctor

Breastfeeding:

Combiflam is safe for use. However, you should discuss the use with your doctor.

Interaction with Other drugs

Combiflam Tablet may interact with the following drugs and products.consult your GP before Using Combiflam with the following drugs.
  • Blood pressure lowering medicine
  • Alcohol
  • Aspirin
  • Warfarin (Risk of Bleeding)
  • Corticosteroids
  • Cyclosporin
  • Reduced effect of asthma medications.
  • Interfere with certain laboratory tests
  • Juxtapid mipomersen
  • Ketoconazole
  • With digoxin used risk that heart failure may be more severe.
  • Leflunomide
  • Lithium drugs
  • Methotrexate
  • Isoniazid
  • Diuretics
  • Other NSAIDs

Note: This is not a complete list of interaction.

Combiflam Side Effects

The following list contains possible side effects that you may experience when using Combiflam Tablet. This is not a complete list. These side effects are possible but not always occur. Some of the side effects can be rare but serious. Consult your doctor if you notice any of the following, especially if they do not disappear.

In addition to the necessary effects, some unwanted effects can be caused by paracetamol. If any of these side effects occur, they may need medical help.

Common

  • Heart Burn
  • Indigestion
  • Nausea
  • Constipation
  • Abdominal pain
  • Gas

Rare side effect

  • Bloody or black, tarry stools
  • Bloody or cloudy urine
  • Fever with or without chills
  • Pain in the lower back
  • Red spots on the skin
  • Skin rash, hives, or itching sore throat
  • Sores, ulcers, or white spots on the lips or in the mouth
  • Sudden decrease in the amount of urine
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Yellow eyes or skin

Dosage

Combiflam is usually given to be used every 6 to 8 hours, as needed, for pain or as directed by your doctor.

Take the drug with a meal or snack to prevent upset stomach.

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