Important Information About Indomethacin

Important Information About Indomethacin

Articles, Drugs
Indomethacin Belongs to group of medicine referred to as nonsteroidal anti-inflammatory drug (NSAID).The federal agency first approved it in january 1965. Indomethacin Uses It is effective in the treatment of gout and ankylosing spondylitis. Effective in the pain of pleurisy and pericarditis. By intravenous admnisttration, it's Effective in the patent ductus arteriosus in premature infants.Thus causes the closure of the ductus that's kept open by prostaglandins. It also can be employed in the prevention of uterine contractions in the premature labour, by inhibiting the formation of prostaglandins. it's harmful for both mother and foetus Pharmacokinetics: It is a potent inhibitor of cyclooxygenase enzyme. once given orally,it is well absorbed from the GIT,metabolized in the liver and excreted in bile and urine. Indomethacin Mechanism Of Action: It works by reducing the…
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Important Information About Levodopa

Important Information About Levodopa

Articles, Drugs
It is used for the treatment of Parkinsonian disorders (associated with low levels of a chemical known as dopamine)and is typically given with agents that inhibit its conversion to dopamine outside of the central nervous system.Levodopa is employed alone or together with carbidopa. Some patients need the combination of medication, whereas others benefit from L-dopa alone. By improving muscle control, L-dopa permits more normal movements of the body.Clinical Uses:In The treatment of Parkinson's disease L-dopa together with carbidopa is at first given in a small dose, like 25/100 mg (25 carbidopa and 100 levodopa) 3 times daily after meals to stop gastric irritation.The dose may be raised upto 25/250 mg 3-4 times daily.However its better to stay the dose of L-dopa low so as to avoid the adverse effects.L-dopa is…
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Important Information About Piroxicam

Important Information About Piroxicam

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Piroxiam Uses:Piroxicam belong to a group of medicine referred to as a nonsteroidal anti-inflammatory drug drug (NSAID) and is one of the first choice drug to reduce Pain, Swelling, and joint stiffness from arthritis,gout, and ankylosing spondylitis. It conjointly sometimes used to relieve pain caused by menstrual cramps, surgery, or vaginal birth.The Food and Drug Administration approved piroxicam in 1982.Mechanism Of Action:It work by reducing the amount of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. It blocks the enzyme that creates prostaglandins (cyclooxygenase), leading to lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.Piroxicam In Pregnancy:Piroxicam might hurt an unborn baby. Don’t take this medication without talking to a doctor if you’re pregnant or conceive to become pregnant.You particularly shouldn’t take It throughout…
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Important information about Domperidone

Important information about Domperidone

Articles, Drugs
Domperidone Uses: Domperidone is a medication that increases the movements or contractions of the stomach and intestine. Domperidone is additionally used to treat nausea and emesis caused by other medicine used to treat parkinson's Diseases uch as levodopa,pramipexole and apomorphine. Mechanism Of Action Domperidone are associated with its dopamine receptor obstruction activity at both the receptor trigger zone and at the gastric level. it's robust affinities for the D2 and D3 dopamine receptors, that are found within the chemoreceptor trigger zone, placed simply outside the blood brain barrier, which - among others - regulates nausea and emesis Contraindications: Domperidone is contraindicated in patients with moderate or severe hepatic impairment, In patients who have noted existing prolongation of cardiac conduction intervals, notably QTc, patients with important electrolyte disturbances or underlying cardiac…
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Tazocin (Piperacillin-Tazobactam)

Tazocin (Piperacillin-Tazobactam)

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Tazocin is the brand name of the combination of piperacillin 2.5 g+ tazobactam 0.25g and it is available in the form of Powder for parenteral injection.This Combination does not increase the activity of piperacillin against pseudomonas.This is due to the fact that pseudomonas produce chromosomal beta lactamases, against which tazobactum is not effective .Antimicrobial spectrum of this combination seems to similar to that of ticarcillin and clavulanate combination. Tazocin Uses Tazocin is used to treat many different infections caused by bacteria, such as Hospital accquired pneumonia,complicated intra abdominal infection, septicaemia (Blood Poisoning), Complicated infection involving urinary tract infections and skin and soft tissue infections. It is also used in infections in neutropenic patients (Low white Blood Count) Mechanism Of Action Tazocin Inhibits bacterial cell wall synthesis by binding to one or…
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Important Information About Rifampicin

Important Information About Rifampicin

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UsesRifampicin is a semisynthetic derivative of rafmycin B obtained from streptomyces mediterranei.Rifampicin is clinically used in the treatment of following Condition:For the Treatment of Tuberculosis in combination with other anti Tuberculosis drugs.Treatment of leprosy and atypical mycobacterial infection.Prevention of Meningococcal meningitis.Prevention of meningitis caused by H.influenza in children.In combination with co-trimxazole for the eradication of staphylococcal infections.Along with Vancomycin,ceftriaxone or cefotoxime ,for the treatment of meningitis caused by highly penicillin resistant pneumococci.Mechanism Of ActionRifampicin is a bactericidal drug and inhibits the synthesis of RNA in the bacterium by inhibition of the enzyme referred to as DNA dependent RNA polymerase.It inhibits DNA dependent RNA synthesis.Probably the basis of selective toxicity is that mammalian RNA polymerase doesn't avidly bind rafampicin.Resistance to Rifampicin could occur due to mutation in the gene of RNA…
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Important Information About Mefenamic Acid

Important Information About Mefenamic Acid

Articles, Drugs
Mefenamic Acid Uses Mefenamic acid (Ponstan) is a Fenamic acid derivatives and is employed in the treatment of pain and inflammation in rheumatoid arthritis and osteoarthritis.Mild to moderate pain,Postoperative pain, menorrhagia (Abnormally heavy periods) and dysmenorrhoea (Painful periods),Pain following surgery, And Pain following childbirth. It has less anti-inflammatory and more harmful effects as compare to aspirin and that is why it mustn't be used for more than one week at a time.It is contraindicated in children and disease like inflammatory bowel disease.It is available in Tablets of 250 and 500 mg. Mechanism Of Action Ponstan contain the active ingredient Mefenamic acid-Which is a type of drugs known as a non-steroidal anti-inflammatory drug (NSAID). NSAIDs are used to relieve pain and inflammation.Mefenamic acid binds the prostaglandin synthetase receptors Cox-1 and Cox-2,…
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Beta 2 Agonist Drugs

Beta 2 Agonist Drugs

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Beta 2 Agonist Drugs (Selective Beta 2 agonists) are the safest drugs and most effective short acting beta 2 agonist for the treatment of asthma while some long acting beta 2 agonist are added to an inhaled corticosteriod. Less Selective beta 2 agonist such as ephedrine should be avoided if possible. Mainly or Selective Beta 2 Agonists produce bronchodilation and It  include: Salbutamol Terbutaline Fenoterol Ritodrine Salmeterol Formoterol 1. Salbutamol: Uses: It is a selective β² agonist and is mainly used as a bronchodilator in the treatment of asthma for this purpose it is best used by inhalation with the help of an inhalaer or nebulizer .When use by inhaltion a smaller dose of drug is required to produce the maximum effect.0.25-0.5 can be used by subcutaneous,intramuscular or slow intrvenous. It…
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Important Information About Cefixime

Important Information About Cefixime

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Cefixime indications/Uses Cefixime is an orally active third generation cephalosporin antibiotics and is employed to treat certain infections caused by bacteria like bronchitis (infection of the airway tubes leading to the lungs); infections of the ears, throat, tonsils, and urinary tract.gonorrhea (a sexually transmitted disease). it's extremely stable in the presence of beta-lactamase enzymes It works by killing bacterium.Antibiotics like cefixime won't work for colds, flu, or different viral infections. using antibiotics when they aren't required will increase your risk of obtaining an infection later that resists antibiotic treatment. Mechanism Of Action Of Cefixime Cefixime binds to specific penicillin-binding proteins (PBPs) situated inside the bacterial cell wall, inflicting the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall…
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Important information About Vigabatrin

Important information About Vigabatrin

Articles, Drugs
Vigabatrin Uses:Vigabatrin is an analogue of gamma aminobutayric acid and  belongs to a group of drugs known as anticonvulsant drugs but it is chemically unrelated to other anticonvulsant drugs.It can be prescribed in combination with other drugs for focal epilepsy with or without secondary generalization.It is also used in partial seizures and as a monotherapy in the treatment of infantile spasm in west's syndrome.Pharmacokinetics:Vigabatrin half life is approximately 6-8 hours but considerable evidence suggest that pharmacodynamic activity of the drug is more prolonged and not well correlated with the plasma half life.Mechansim Of Action:Vigabatrin inhibits irreversibly the enzyme GABA aminotransferase ( enzyme causing metabolism of GABA),Thus, increasing the concentration of GABA at its synapses. It may also work by suppressing repetitive neuronal firing through blocking of voltage-sensitive sodium channels.Side Effects:More…
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