Aceclofenac (brand name: Airtal) belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs).
Aceclofenac is indicated for the relief of
- Pain and inflammation in osteoarthritis
- Rheumatoid arthritis and
- Ankylosing spondylitis
- It is also used in fever, toothache. Headaches, Postoperative pain
Airtal should not be administered to people with porphyria or nursing mothers and is not recommended for children.
Use with caution in
- People with a history of stomach or intestinal disorders.
- Inflammatory bowel disease such as Crohn’s disease or ulcerative colitis.
- Old people
- Kidney disease.
- High blood pressure (hypertension).
- Liver disease
- People with high levels of fat, such as blood cholesterol (hyperlipidemia).
- Connective tissue diseases, for example, systemic lupus erythematosus.
- People with blood clotting disorders or taking blood-thinning medications.
- People with a history of allergies
- People with a history of asthma.
- Aceclofenac is rapidly and completely absorbed from the gastrointestinal tract and circulates drug mainly as unchanged after oral administration. It is reported that it is very close to proteins (> 99%).
- The volume of distribution is approximately 25 L.
- It is reported that it is very close to proteins (> 99%).
- The plasma elimination half-life is approximately 4 hours.
- The elimination rate is approximately 5 l / h.
Mechanism of action
Aceclofenac (Airtal) works by blocking the action of natural substances called cyclooxygenase (COX) enzymes. These enzymes help form other chemicals in the body called prostaglandins. Some prostaglandins are produced in injured or damaged areas that cause pain and inflammation. By blocking the action of COX enzymes, less prostaglandins are produced, which relieves pain and inflammation.
Airtal Side effects
Side effects associated with the use of aceclofenac include:
- Nausea and vomiting
- Nausea and vomiting
- Mouth ulcer
- Inflammation of the stomach
- Increase of urea and creatinine in the blood.
If you notice any of the above side effects, contact your doctor immediately.
Airtal in pregnancy
It is a category B drug, which means that studies of reproduction either in animals have shown no fetal risk but no controlled studies in pregnant women or animals reproductive studies have shown an adverse effect (other than a decrease in fertility). that was not confirmed.Should be avoided in pregnant women due to the risk of ductus arteriosus in the newborn.
The recommended dose for adult is 200 mg per day in two separate doses of 100 mg, one tablet in the morning and one in the evening.
Usual dose in elderly, If an NSAID is considered necessary, the lowest effective dose and the shortest possible duration should be used. The patient should be monitored for gastrointestinal bleeding regularly during treatment with NSAIDs.
There are no clinical data on the use of aceclofenac in children and therefore its use in children under 18 years is not recommended.
Signs and symptoms of overdose are rashes, confusion, chest pain, blurred vision, etc. After confirmation of an overdose, immediate medical attention is required.