Clobetasol (Clovate)  belongs to a group of drugs known as glucocorticoids and is used for the short-term topical treatment of inflammatory and pruritic manifestations of corticosteroid sensitive to moderate to severe dermatosis of the scalp. It is also very effective for contact dermatitis due to exposure to poison ivy / oak

Clovate uses

These include the following:

  • Psoriasis (without disseminated plaque psoriasis)
  • Lichen planus
  • Recalcitrant dermatoses
  • Discoid lupus erythematosus

Mechanism of action:

It is believed that corticosteroids act by inducing proteins that inhibit phospholipase A2, collectively called lipocortins. It has been postulated that these proteins control the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Phospholipase A2 releases arachidonic acid from membrane phospholipids. First, however, Clobetasol binds like other corticosteroids to the glucocorticoid receptor, which penetrates the nucleus and transcriptional genetics (transrepression / transactivation) changed.

Side effects of Clovate

Topical clobetasol cream does not cause drowsiness. However, it causes other side effects.

  • The most common side effects with Clobetasol include: burning, irritation and itching of the skin to which Clovat has been applied.
  • Serious side effects and symptoms may include: adrenal insufficiency, Cushing’s syndrome, high blood sugar levels, and high blood pressure.

Less serious side effects include

  • Dry or cracked skin;
  • Mild rash, itching, burning or redness
  • Thinning or softening of your skin;
  • Rash or irritation around the mouth
  • Temporary hair loss;
  • Spider veins;
  • Swollen hair follicles;
  • Changes in the color of the treated skin;
  • Stretch marks
  • Blisters, pimples or incrustations of the treated skin.

Clovate Precautions

A very serious allergic reaction to this medication before using Clovate (clobetasol), tell your doctor or pharmacist if you are allergic to it; or to any other steroid (eg, hydrocortisone, dexamethasone); or if you have any other allergies This product may contain inactive ingredients that may cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have medical history, of poor circulation, diabetes, other skin diseases (such as rosacea, perioral dermatitis), immune system problems.

Clovate in pregnancy

This medication should only be used if clearly needed during pregnancy. It is not known if this medicine passes into breast milk when it is applied to the skin. Discuss the risks and benefits with your doctor

Clovate Dosage

The usual dose for adults and children in the treatment of dermatitis, eczema and psoriasis 50 g (50 ml or 1.75 fl oz) per week should not exceed. Not recommended for children under 18 years.

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